SYNTHESIS METHOD FOR STABLE-ISOTOPE LABELED FLORFENICOL AND FLORFENICOL AMINE - 佰腾网专利查询 - 全球专利搜索领导品牌

A synthesis method for stable-isotope labeled florfenicol and florfenicol amine. The method uses florfenicol as a raw material, and comprises hydrolyzing same to obtain florfenicol amine, performing hydrogen-deuterium exchange under an alkaline condition to obtain stable-isotope labeled florfenicol amine, and further performing acylation to obtain stable-isotope labeled florfenicol. The synthesis method involves a short synthesis route, high atom utilization rate, high yield and cheap and easily available raw materials. The chemical purity and deuterium isotope abundance of the prepared stable-isotope labeled florfenicol and florfenicol amine both reach 98.0% or higher, and therefore the stable-isotope labeled florfenicol and florfenicol amine can be used as isotope internal standard substances for analysis and detection. - 佰腾网专利查询 - 全球专利搜索领导品牌